There are four new faces in the Quins squad which looks to start this season in the fabulous way it finished the last one. Kick of at Newcastle Falcons is at 3.00 on Sunday - live on BT Sport.
Summer signings Jack Walker (hooker) and Tommy Allan (fly half|) start with prop Craig Trenier on the bench along with Scotland centre Huw Jones.
Marcus Smith will be missing as he enjoys his enforced three match rest after returning from his suddeen call to join the Lions.
Stephan Lewis is also missiing so Alex Dombrandt takes over the leadership.
There's also great interest in replacement hooker Craig Riley who scored a couple in pre-season and who figured strongly for England Under 20's.
Mike Brown won't be playing for Falcons as he has picked up a rib injury in pre-season
Quins: Tyrone Green, Louis Lynagh, Joe Marchant, Andre Esterhuizen, Cadan Murley, Tommy Allan, Danny Care, Santiago Garcia Botta, Jack Walker, Simon Kerrod, Matt Symons, Dino Lamb, Tom Lawday, Jack Kenningham, Alex Dombrandt (captain).
Replacements: Sam Riley, Joe Marler, Craig Trenier, Hugh Tizard, Archie White, Scott Steele, Huw Jones , Luke Northmore.
Falcons: Tom Penny, Adam Radwan, Ben Stevenson, Pete Lucock, Iwan Stephens, Brett Connon, Louis Schreuder; Logovi’i Mulipola, George McGuigan, Trevor Davison, Greg Peterson, Sean Robinson, Philip van der Walt, Will Welch (captain), Carl Fearns.
Replacements: Jamie Blamire, Kyle Cooper, Mark Tampin, Marco Fuser, Connor Collett, Cameron Nordli-Kelemeti, Will Haydon-Wood, George Wacokecoke.
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