Staying @ home
Hargreaves played no part in Saturday's friendly at Aberdeen and is reportedly having further trouble with a knee problem.
Meanwhile, van der Sar, Nani and Patrice Evra are all rested after participating in Euro 2008 - whilst want-away Ronaldo is recovering from ankle surgery.
Ji-Sung Park has a leg injury and will not travel; whilst Louis Saha's exclusion will help fuel speculation that he's set to leave the club in the coming weeks.
Fraizer Campbell looks certain to win a chance to impress on the tour as he joins Wayne Rooney and Carlos Tevez as one of strikers making the trip.
The United squad are jumping on a 2pm flight from Manchester airport where they will make the long-haul flight to Cape Town.
United's trip to South Africa kicks-off with friendly matches against Kaizer Chiefs and the Orlando Pirates on the 19th and 22nd of July. The two Soweto teams will then battle it out for the right to play United a second time - this time with the Vodacom Challenge Cup on the line.
The Red Devils then journey up to Nigeria for a needless friendly against F.A Cup holders Pompey. The game will be a dress rehearsal for the Community Shield match on August 10th at Wembley.
On their return to English shores, United play matches against Espanyol, Peterborough United and Juventus before the competitive action gets underway.
The 21-man squad travelling to the African continent is listed below.
Goalkeepers: Ben Amos, Ben Foster, Tomasz Kuszczak
Defenders: Wes Brown, Jonathan Evans, Rio Ferdinand, Gary Neville, John O'Shea, Mikael Silvestre, Danny Simpson, Nemanja Vidic
Midfielders: Michael Carrick, Chris Eagles, Darren Fletcher, Darron Gibson, Ryan Giggs, Lee Martin, Paul Scholes
Forwards: Fraizer Campbell, Wayne Rooney, Carlos Tevez
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